Wednesday, December 11, 2019

Discussion on Drug-Metabolism Enzyme

Question: How do enzyme kinetics affect an individuals response to therapeutic and other drugs. Answer: One can call the drug-metabolism enzyme as the mixed function oxidase, or the mono-oxygenase (Bishop, Fody Schoeff, 2013). The particular enzyme contains the cytochrome P450. Along with it, the particular enzyme contains the cytochrome b5. Other than these components, components like NADPH-cytochrome P450 reductase, along with other components are included in it at the same time. The CY or the hepatic cytochrome P450s belongs to a multi-gene family and thus plays an important role in the process of metabolism (Zanger Schwab 2013). References Bishop, M. L., Fody, E. P., Schoeff, L. E. (Eds.). (2013).Clinical Chemistry: Principles, Techniques, and Correlations. Lippincott Williams Wilkins. Zanger, U. M., Schwab, M. (2013). Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation.Pharmacology therapeutics,138(1), 103-1

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